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Zylast is truly a revolution in hand hygiene, and is one of the most extensively tested products on the market.  In clinical studies, Zylast has reduced illness in hospitals, nursing homes, and schools.


Zylast has proven to be superior to traditional alcohol sanitizer in several settings.  In a study in hospitals, replacing a traditional alcohol sanitizer with Zylast reduced hospital-acquired infections (HAIs) by 20%.  In the same study, the staff also noted that using Zylast significant improved how their hands felt, reducing dryness (24%) while improving skin appearance (41%) and overall hand feel (40%).

This is the first clinical study in which a specific leave-on sanitizer has been demonstrated to reduce nosocomial infections over an alcohol sanitizer.


*Cozean J, Czerwinski S, Cozean C. Reduction of Hospital-Acquired Infections with the Use of a Hand Sanitizer with Both Immediate and Persistent Antimicrobial Effect. O. Jour. of Inf. Diseases & Epidemiology, 1:1; 22-27, 2017


In a clinical study, alcohol-based sanitizers in a long-term care facility were replaced with persistent Zylast Antiseptic.  Making this change significantly reduced nosocomial infections.  Overall, infections were down by 17%, with significant reductions in upper respiratory tract infections, ears/eyes/nose/throat infections, and other infections.


*Czerwinski S & Cozean J. Use of a Persistent, Water-Based Hand Sanitizer with Anti-Viral Properties Reduces Nosocomial Infection in Long Term Care Facility. J. Immunol Tech Infect Dis, 6:3, 2017


The FDA says: "Persistence, defined as prolonged activity, is a valuable attribute that assures antimicrobial activity during the interval between washings, and is important to a safe and effective healthcare personnel handwash."  However, standard alcohol sanitizers have no persistence.  Zylast has been tested for persistent effect, demonstrating more than a 99.9% kill level 6 hours after application in independent testing.


*Czerwinski S, Cozean J, Taylor T, McGovern K, Cozean C. Novel Persistent Products Significantly Reduce In-Vivo Transmission of Transient Pathogens. BIT Annual Global Health Conference, 2016.


Zylast was tested in schools for its ability to prevent illness absenteeism and outbreaks.  In the two schools tested, adding Zylast reduced illness absenteeism among students by 39% and among staff by 24%.  Even more incredibly, illness outbreaks - when more than 10% of the class was sick - were reduced by nearly 90%.


*Keeney B, Cozean J et al, Reducing Illness Absenteeism and Outbreaks Among Students with Persistent, Water-based Antiseptic Products in a Controlled, Crossover Clinical Study.  Int. J. Microbiol Infect Dis, 1(2) 2017


Healthcare workers use hand sanitizers every few minutes, often more than 100 times each day.  Their hands become irritated, cracked, and dry, leading to increased chances for infection among patients and the staff.  When a standard alcohol sanitizer was replaced with the Zylast Antiseptic Lotion, the Overall Hand Feel" of workers went up by 40%!  In fact, there was an improvement with Zylast in every category studied.  Zylast adds moisture back into the skin and was shown to reduce irritation over alcohol sanitizers in medical settings.


*Cozean J, Czerwinski S, Cozean C. Reduction of Hospital-Acquired Infections with the Use of a Hand Sanitizer with Both Immediate and Persistent Antimicrobial Effect. O. Jour. of Inf. Diseases & Epidemiology, 1:1; 22-27, 2017


Alcohol sanitizers have been shown to make hand hygiene faster and improve compliance, but have never been demonstrated in a controlled, crossover clinical trial to reduce HAIs (Doebbeling et al, 1992; Larsen et al, 2005; Rupp et al, 2008).  Zylast is the first hand sanitizer to reduce hospital infections in the same trial, showing a reduction of 23.1% in nosocomial infections in a hospital trial of more than 6,000 patients.


*Kampiatu, P. and Cozean, J., A controlled, crossover study of a persistent antiseptic to reduce hospital-acquired infection, AJID. 9(1): 6-9, 2014


In a historically controlled clinical trial at a 325 bed hospital over three years, Zylast Antiseptic Lotion and Zylast Antiseptic Foaming Soap as compared to an alcohol-based hand sanitizer (Steris, 62% ethanol) and PCMX soap, the hospital showed a statistically significant reduction in overall hospital acquire infections (0%), C. difficile (28%), and VRE (40%) and a reduction in MRSA (14%).



Using the standard time-kill method, the Zylast products were compared against a standard alchohol - based sanitizer.
Both the Antiseptic and Antiseptic Lotion outperformed the Avagard D sanitizer against all 9 organisms tested.


PACE University, Haskins Laboratories, Wash Off Testing of Zylast Persistent Soap, April 19, 2012


Norovirus is the leading cause of gastroenteritis, causing diarrhea, vomiting and severe abdominal pain.  Alcohol sanitizers have been shown to be relatively ineffective against the Norovirus – actually less effective than rinsing hands with water.1 Nursing homes that rely on alcohol sanitizers are six times more likely to have a norovirus outbreak than those that use handwashing alone.2  In contrast, the Zylast Antiseptic was shown to kill 99.97% of the norovirus surrogate on human skin at contact.3

1  Liu P et al, Effectiveness of Liquid Soap and Hand Sanitizer against Norwalk Virus on Contaminated Hands, Appl Environ Microbiol. 2010 Jan;76(2):394-9

2  Blaney D et al, Use of alcohol-based hand sanitizers as a risk factor for norovirus outbreaks in long-term care facilities in northern New England: December 2006 to March 2007, American Journal of Infection Control, 39 (4) 296-301, 2011

3  Czerwinski SE, Cozean J, An evaluation of a Hand Sanitizer Product to Reduce Norovirus Cross Infection, British Global Travel Health Association Journal, 20: 42-46, 2012


How it Works

The Zylast technology is a synergistic combination of ingredients centered around the antimicrobial benzethonium chloride (BZT) or benzalkonium chloride (BZK), designed to provide both immediate and persistent kill of pathogens while eliminating the skin irritation associated with harsh sanitizers.

BZT is a well-known antimicrobial agent that has been in use since the 1970s in wound care and antiseptic applications, which works by lysing the cell membrane of germs and causing them to dissolve.   It is known to be safe and non-irritating, but has never been shown to work quickly or powerfully enough against germs to be a widespread alternative to alcohol sanitizers. It is included in the FDA Tentative Final Monograph for First Aid Antiseptics.

BZK is also a well-known antimicrobial agent that is in the FDA Final Monograph for Healthcare and Consumer Antiseptics. 

BZT and BZK work by changing the permeability of the cell membrane and are effective against gram positive bacteria, gram negative bacteria, resistant bacteria, viruses, fungi, mold and yeast.  By combining the BZT or BZK with ingredients that amplify the antimicrobial effect, the Zylast technology has created a non-irritating sanitizer that can kill germs just as quickly as alcohol products.  Specifically designed to stay on the hands and kill transient bacteria, Zylast provides persistent protection for six hours.  It also inherently moisturizes the hands.  Zylast has been shown to reduce illness absenteeism in schools and hospital-acquired infections over traditional sanitizers and hand washing.

Patents and Trademarks

Zylast has patents and pending patents in the United States and worldwide (US Patents: 9,717,669; 10,010,496; and 0,524,997). Zylast® is a registered trademark of Innovative BioDefense, Inc., a California-based U.S. company.

Active Ingredients

            Zylast Antiseptic and Antiseptic S – Ethyl Alcohol

            Zylast Antiseptic Lotion and Antiseptic Foaming Soap – Benzethonium Chloride

            Zylast Antiseptic Lotion K – Benzalkonium Chloride


Natural Ingredients

All ingredients, except the antimicrobial QUATS, within the Zylast products are natural. For a list of ingredients see attached labels.

Green Manufacturing

All Zylast Products are manufactured per FDA regulations in an award-winning Green Manufacturing U.S. facility that is solar-powered.  Packaging materials used in Zylast Products are biodegradable.


BZT and BZK are some of the most-studied compounds in history.  mBZT came on the market in the 1950s for use in hospitals, operating suites, for consumers and in first aid.  BZT is considered safe and effective in concentrations of 0.1-0.2% by the FDA when used on open wounds for first aid.  BZK is cleared in the Healthcare and Consumer Final Monographs as an antiseptic by the FDA. Ethyl Alcohol is also commonly and safely used in most hand sanitizers.  Warnings: Flammable when exposed to open flames and toxic if swallowed.